Endotoxins

What are Endotoxins?
 
Endotoxins are toxins that are released by bacteria into the environment, which are toxins kept within the bacterial cell and are released only after destruction of the bacterial cell wall.
 
Today, the term 'endotoxin' is used synonymously to the term lipopolysaccharide, which is a major constituent of the outer cell wall of Gram-negative bacteria. Larger amounts of endotoxins can be mobilized if Gram-negative bacteria are killed or destroyed by detergents mainly during mold remediation projects, or basic attempts to clean an area.
 
The term "endotoxin" came from the discovery that portions of Gram-negative bacteria themselves can cause toxicity, hence the name endotoxin. Studies of endotoxins over the last 50 years revealed the key effects of endotoxins on humans and animals. They are mediated by their interaction with specific receptors on immune cells such as monocytes, macrophages, dendritic cells, and others effecting the immune system. Endotoxins have been shown to act synergistically with mycotoxins (trichothecenes, ochratoxin A and aflatoxins) in animal models and tissue culture assays.
 
It is important to address these issues as well as any fungal issues when there is an environmental exposure. Failure to do so will result in the patient receiving treatment, feeling better for a short time then suffering relapse.